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Documenti acquisiti e normalizzati dal repository locale. Questa vista è generale e non rappresenta i risultati di una ricerca clinica personale.
3236 documenti indicizzati nel repository · vista pubblica filtrata sul carcinoma mammario esplicito
Deformable Discoidal Polymeric Nanoconstructs (DPN) represent a biomimetic drug-delivery platform designed to overcome the limitations of conventional spherical nanoparticles. Their discoidal geometry, tunable deformability, and PLGA/PEG-based composition promote vascular margination, reduce phagocytic sequestration, prolong circulation, and enhance accumulation at pathological sites. This…
Tipo: publication · Data: 2026-09-22 · PMID 42771054 · DOI 10.1007/s10544-026-00854-6
Breast cancer heterogeneity and its complex tumor microenvironment (TME) are key drivers of therapeutic failure and multidrug resistance (MDR). Drug delivery systems (DDS) provide an important approach, but their clinical translation remains limited by biological variability, formulation complexity, and manufacturing challenges. This…
Tipo: publication · Data: 2026-09-22 · PMID 42801248 · DOI 10.2147/dddt.s638939
Doxorubicin (DOX) is a widely used first-line chemotherapeutic drug with potent anti-tumor activity, yet severe off-target cardiotoxicity and hepatotoxicity severely restrict its clinical application. This study aimed to construct an ultrasound-responsive PLGA microbubble delivery system to realize tumor-specific controlled DOX release under…
Tipo: publication · Data: 2026-09-23 · PMID 42776623 · DOI 10.1080/09205063.2026.2736152
Invasive lobular carcinoma (ILC) is the second most common subtype of breast cancer after invasive carcinoma of no special type (NST), previously referred to as invasive ductal carcinoma. Loss of E-cadherin-mediated adhesion drives its characteristic diffuse infiltration, producing subtle or ill-defined lesions…
Tipo: publication · Data: 2026-08-06 · PMID 42571762 · DOI 10.1016/j.ejrad.2026.113152
Tipo: publication_metadata · Data: 2015-08-30 · DOI 10.14738/jbemi.24.1308
Breast cancer represents the most frequently diagnosed malignancy in women, with the hormone receptor-positive/HER2-negative (HR+/HER2-) subtype being the most prevalent. For advanced HR+/HER2- breast cancer, the combination of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) with endocrine therapy has become the established first-line standard,…
Tipo: publication · Data: 2026-03-13 · PMID 41907622 · DOI 10.3389/fonc.2026.1763278
Introduction: Cervical cancer is the second most common gynaecological cancer after breast cancer in low-middle income countries, particularly Morocco. Worldwide, cervical cancer is the 4th most frequently diagnosed cancer and the 4th leading cause of cancer-related death in women. Its pathogenesis is…
Tipo: publication_metadata · Data: 2025-03-13 · DOI 10.14738/bjhmr.122.18298
Tipo: publication_metadata · Data: 2022-06-29 · DOI 10.14738/jbemi.93.12535
Tipo: publication_metadata · Data: 2022-10-08 · DOI 10.14738/jbemi.95.13114
Multiple trials confirm systemic T-DXd efficacy in HER2+ breast cancer with leptomeningeal/brain metastases, yet median LM survival remains 3-4 months, highlighting unmet needs. While systemic therapies improve survival, intracranial disease control remains limited due to poor BBB penetration. Preclinical data show no…
Tipo: trial · Data: 2025-08-21 · NCT NCT07134153
This study will test the safety, including side effects, and determine the characteristics of a drug called Rina-S in participants with solid tumors. Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with surgery…
Tipo: trial · Data: 2026-08-04 · NCT NCT05579366
This is a prospective, open-label, multi-cohort, phase II study to evaluate the efficacy and safety of Oral metronomic capecitabine combined with pyrotinib in patients with HER2-positive advanced breast cancer who had received prior anti-HER2 ADC drugs (including T-DXd, SHR-A1811, T-DM1, etc.) before…
Tipo: trial · Data: 2025-06-13 · NCT NCT07019337
The goal of this study is to characterize early dynamic changes in ctDNA, which can aid in tailoring early therapy in patients with metastatic Invasive lobular carcinoma (ILC). Response assessment using ctDNA analysis could not only aid in de-escalation but also escalation…
Tipo: trial · Data: 2026-01-20 · NCT NCT06666439
The goal of this multi-centre, prospective study is to assess the frequency of asymptomatic brain metastasis in patients with stage IIb or III Triple Negative or HER2 positive breast cancer. The main questions it aims to answer are: 1. What proportion of…
Tipo: trial · Data: 2025-12-18 · NCT NCT06247449
Tipo: publication_metadata · Data: 2026-08-01 · DOI 10.1016/j.cej.2026.177740
Breast cancer is the most prevalent malignancy in the world and the leading cause of female cancer-related mortality. Several ways for combating this entity have been proposed, but a significant and effective cure has yet to be established. Natural compounds originating from…
Tipo: publication_metadata · Data: 2023-04-28 · DOI 10.33640/2405-609x.3273
Objectives: Clusterin (CLU) has been implicated in cell survival and treatment resistance, but its relationship with pathological response to neoadjuvant chemotherapy in breast cancer remains unclear. We evaluated CLU expression in routine diagnostic specimens as a biomarker of pathological response and long-term…
Tipo: publication_metadata · Data: 2026-09-29 · DOI 10.3390/jcm15197557
The purpose of this study is to investigate the efficacy, safety, and tolerability of camizestrant in combination with ribociclib in patients with ER+ HER2- BC who have not received any other systemic treatment for advanced disease. Participants will be treated within the…
Tipo: trial · Data: 2026-08-10 · NCT NCT07647328
This phase II trial studies how well genetic testing works in predicting tumor response in patients with stage I-III HER2 negative invasive breast cancer. Genetic testing is a procedure that tests tumor samples to learn if certain genes are activated (turned on)…
Tipo: trial · Data: 2026-09-18 · NCT NCT01334021
The safety of omitting sentinel lymph node biopsy (SLNB) has been established only in patients undergoing breast-conserving surgery with whole-breast radiotherapy, as demonstrated in the prior randomized trials. Whether SLNB can be omitted in patients who will not receive whole-breast radiotherapy remains…
Tipo: trial · Data: 2026-09-25 · NCT NCT07841704
This study assesses if metastasis-directed radiation therapy (Stereotactic body radiation therapy - SBRT) can delay a change in systemic therapy, and if circulating tumor cells in the bloodstream can help guide treatment options in metastatic breast cancer patients with progressive disease
Tipo: trial · Data: 2026-09-03 · NCT NCT06055881
Breast cancer is biologically heterogeneous, yet conventional clinical decisions rely on static, single-marker proxies (ER, PR, HER2, and Ki-67) that capture only a narrow slice of tumor biology. This mini-review argues that AI-driven multi-omics biomarkers offer a valuable shift toward systems-level, model-derived…
Tipo: publication_metadata · Data: 2026-09-29 · DOI 10.3389/fphar.2026.1953714
This is a descriptive, exploratory cross-sectional, single-center national study. The study asks a sample of women carrying pathogenic variants associated with hereditary breast and ovarian cancer who have undergone risk-reducing mastectomy (MRR) and have signed informed consent to complete an interview developed…
Tipo: trial · Data: 2026-09-16 · NCT NCT07821593
Drawing on scholarship in feminist studies, sociolinguistics, and cultural studies, this article-diary argues that motherhood—particularly as experienced by an Arab woman navigating personal loss, specifically the loss of a breast to cancer, and societal expectations—is not a static role but a dynamic…
Tipo: publication_metadata · Data: 2025-03-31 · DOI 10.25071/8sgykq15
Tipo: publication_metadata · Data: 2024-01-01 · DOI 10.1016/j.heliyon.2023.e23827
Tipo: publication_metadata · Data: 2024-01-01 · DOI 10.1016/j.heliyon.2023.e23383
ABSTRACT Metastasis of invasive ductal carcinoma of the breast to the uterine cervix is rare, with only one report of a case occurring more than 20 years after the primary surgery. A 69‐year‐old woman presented with abnormal uterine cervical cytology (atypical glandular cells…
Tipo: publication_metadata · Data: 2026-09-28 · DOI 10.1111/jog.70509
Tipo: publication_metadata · Data: 2000-07-01 · DOI 10.1117/1.430006
Tipo: publication_metadata · Data: 2000-04-01 · DOI 10.1117/1.429990
Abstract Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is highly aggressive and is associated with poor prognosis after metastasis or recurrence. The development of anti-HER2 antibody–drug conjugates (ADCs) has markedly improved outcomes. Disitamab vedotin (RC48) is a novel anti-HER2 ADC…
Tipo: publication_metadata · Data: 2026-09-29 · DOI 10.1186/s13046-026-03836-x
Tipo: publication_metadata · Data: 2027-01-01 · DOI 10.1016/j.snb.2026.140965
Tipo: publication_metadata · Data: 2026-09-30 · DOI 10.15616/bsl.2026.32.3.242
There is increasing attention to prevention as a means to reduce cancer incidence. Prevention interventions or therapies in turn rely on risk assessment programs to identify those women most likely to benefit from education and lifestyle changes. These programs are usually based…
Tipo: publication_metadata · Data: 2004-07-01 · DOI 10.1117/1.1758269
We describe the use of a biochip based on complementary metal oxide semiconductor (CMOS) technology for detection of specific genetic sequences using molecular beacons (MB) immobilized on solid surfaces as probes. The applicability of this miniature detection system for screening for the…
Tipo: publication_metadata · Data: 2004-05-01 · DOI 10.1117/1.1691025
Molecular targeting with exogenous near-infrared excitable fluorescent agents using time-dependent imaging techniques may enable diagnostic imaging of breast cancer and prognostic imaging of sentinel lymph nodes within the breast. However, prior to the administration of unproven contrast agents, phantom studies on clinically…
Tipo: publication_metadata · Data: 2004-05-01 · DOI 10.1117/1.1691027
We present a frequency-domain near-infrared optical tomography system designed for breast cancer detection, in conjunction with conventional ultrasound. It features fast optical switching, three-wavelength excitations, and avalanche photodiode as detectors. Laser diodes at 660, 780, and 830 nm are used as light…
Tipo: publication_metadata · Data: 2004-05-01 · DOI 10.1117/1.1695410
Near-infrared (NIR) diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) show promise as noninvasive clinical techniques for breast cancer screening and diagnosis. Since NIR methods are based on optical contrast between healthy and diseased tissue, it is essential to characterize the…
Tipo: publication_metadata · Data: 2004-05-01 · DOI 10.1117/1.1695560
Tipo: publication_metadata · Data: 2004-01-01 · DOI 10.1117/1.1629681
Abstract Background We have previously demonstrated that the linear decrease in postmenopausal breast cancer incidence with increasing parity is linked to expression changes in hundreds of genes in the peripheral blood cells of healthy women. However, these changes are not observed in…
Tipo: publication_metadata · Data: 2026-09-29 · DOI 10.1186/s12885-026-17044-5
Abstract Breast cancer remains a major global health burden and is characterized by substantial molecular and clinical heterogeneity. In recent years, considerable progress has been made in elucidating the genetic and molecular mechanisms underlying breast cancer, particularly those associated with hereditary susceptibility.…
Tipo: publication_metadata · Data: 2026-09-28 · DOI 10.1186/s41065-026-00720-8
Diffuse optical imaging (DOI) may be a beneficial diagnostic method for women with mammographically dense breast tissue. In order to evaluate the utility of DOI, we are developing broadband diffuse optical spectroscopy (DOS) to characterize the functional origins of optical signals in…
Tipo: publication_metadata · Data: 2006-07-01 · DOI 10.1117/1.2337546
Tipo: publication_metadata · Data: 2026-09-29 · DOI 10.24875/j.gamo.m26000287
The fibrillar collagen network in tumor and normal tissues is different due to remodeling of the extracellular matrix during the malignant process. Collagen type I fibers have the crystalline and noncentrosymmetric properties required for generating the second-harmonic signal. The content and structure…
Tipo: publication_metadata · Data: 2008-09-01 · DOI 10.1117/1.2983664
We study the spectral correlation properties of the polarized fluorescence spectra of normal and cancerous human breast tissues, corresponding to patients belonging to diverse age groups and socioeconomic backgrounds. The emission range in the visible wavelength regime of 500 to 700 nm…
Tipo: publication_metadata · Data: 2008-09-01 · DOI 10.1117/1.2997376
An automated procedure for detecting breast cancer using near-infrared (NIR) tomographic images is presented. This classification procedure automatically extracts attributes from three imaging parameters obtained by an NIR imaging system. These parameters include tissue absorption and reduced scattering coefficients, as well as…
Tipo: publication_metadata · Data: 2008-07-01 · DOI 10.1117/1.2956662
Diffuse optical tomography has shown promising results as a tool for breast cancer screening and monitoring response to chemotherapy. Dynamic imaging of the transient response of the breast to an external stimulus, such as pressure or a respiratory maneuver, can provide additional…
Tipo: publication_metadata · Data: 2011-07-01 · DOI 10.1117/1.3599955
The accurate and rapid assessment of tumor margins during breast cancer resection using optical coherence tomography (OCT) has the potential to reduce patient risk. However, it is difficult to subjectively distinguish cancer from normal fibroglandular stromal tissues in OCT images, and an…
Tipo: publication_metadata · Data: 2011-06-01 · DOI 10.1117/1.3590746
The design and testing of a pneumatic optical positioning interface produced with the goal of improving fiber positioning in magnetic resonance (MR)-guided diffuse spectral imaging of breast cancer is presented. The system was created for vertical positioning of optical fibers inside the…
Tipo: publication_metadata · Data: 2011-06-01 · DOI 10.1117/1.3587631
Cancer-related enzyme activity can be detected noninvasively using activatable fluorescent molecular probes. In contrast to "always-on" fluorescent molecular probes, activatable probes are relatively nonfluorescent at the time of administration due to intramolecular fluorescence resonance energy transfer (FRET). Enzyme-mediated hydrolysis of peptide linkers…
Tipo: publication_metadata · Data: 2011-06-01 · DOI 10.1117/1.3594153
The identification of breast cancer patients who will ultimately progress to metastatic disease is of significant clinical importance. The quantification and assessment of circulating tumor cells (CTCs) has been proposed as one strategy to monitor treatment effectiveness and disease prognosis. However, CTCs…
Tipo: publication_metadata · Data: 2011-04-01 · DOI 10.1117/1.3560624