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3237 documenti indicizzati nel repository · vista pubblica filtrata sul carcinoma mammario esplicito
Collection of CSF Samples From Participants With Metastatic Triple Negative Breast Cancer (TNBC) and HER2+ Breast Cancer With no Prior History Nor Active Radiographically Detectable Brain Metastases
Background: Breast cancer is the most common cancer among women. It can often spread to the liver, lungs, bones, or brain. Breast cancer that spreads to the brain is often fatal. Researchers want to know if tumor DNA found in spinal fluid,…
Deformable discoidal polymeric nanoconstructs: Design principles, therapeutic applications, and translational perspectives.
Deformable Discoidal Polymeric Nanoconstructs (DPN) represent a biomimetic drug-delivery platform designed to overcome the limitations of conventional spherical nanoparticles. Their discoidal geometry, tunable deformability, and PLGA/PEG-based composition promote vascular margination, reduce phagocytic sequestration, prolong circulation, and enhance accumulation at pathological sites. This…
Advances in Drug Delivery Systems for Breast Cancer: From Microenvironment Barriers and Smart Carriers to Clinical Translation Strategies.
Breast cancer heterogeneity and its complex tumor microenvironment (TME) are key drivers of therapeutic failure and multidrug resistance (MDR). Drug delivery systems (DDS) provide an important approach, but their clinical translation remains limited by biological variability, formulation complexity, and manufacturing challenges. This…
Sono-dynamic synergy of DOX-MBs achieves real-time imaging-guided drug delivery for breast cancer.
Doxorubicin (DOX) is a widely used first-line chemotherapeutic drug with potent anti-tumor activity, yet severe off-target cardiotoxicity and hepatotoxicity severely restrict its clinical application. This study aimed to construct an ultrasound-responsive PLGA microbubble delivery system to realize tumor-specific controlled DOX release under…
Imaging patterns and diagnostic challenges in metastatic invasive lobular carcinoma.
Invasive lobular carcinoma (ILC) is the second most common subtype of breast cancer after invasive carcinoma of no special type (NST), previously referred to as invasive ductal carcinoma. Loss of E-cadherin-mediated adhesion drives its characteristic diffuse infiltration, producing subtle or ill-defined lesions…
Fourier Transform Based Early Detection of Breast Cancer by Mammogram Image Processing
Therapeutic advances in HR+/HER2- advanced breast cancer after failure of CDK4/6 inhibitor therapy.
Breast cancer represents the most frequently diagnosed malignancy in women, with the hormone receptor-positive/HER2-negative (HR+/HER2-) subtype being the most prevalent. For advanced HR+/HER2- breast cancer, the combination of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) with endocrine therapy has become the established first-line standard,…
Cervical Cancer: Epidemiological, Clinical and Therapeutic Aspects Experience of the Mohamed VI Center for Cancer Treatment
Introduction: Cervical cancer is the second most common gynaecological cancer after breast cancer in low-middle income countries, particularly Morocco. Worldwide, cervical cancer is the 4th most frequently diagnosed cancer and the 4th leading cause of cancer-related death in women. Its pathogenesis is…
The Prospective Benefits of Using Machine Learning for the Prediction of Breast Cancer
Clinicopathologic Profile and Review of Breast Cancer Patients in a Resource Limited Setting: The Unimedthc Experience
Phase I/II Study of Intrathecal/Ommaya T-DXd in HER2-Expressing Breast Cancer With Leptomeningeal/Brain Metastases
Multiple trials confirm systemic T-DXd efficacy in HER2+ breast cancer with leptomeningeal/brain metastases, yet median LM survival remains 3-4 months, highlighting unmet needs. While systemic therapies improve survival, intracranial disease control remains limited due to poor BBB penetration. Preclinical data show no…
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
This study will test the safety, including side effects, and determine the characteristics of a drug called Rina-S in participants with solid tumors. Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with surgery…
Oral Metronomic Capecitabine Combined With Pyrotinib in ADC-treated HER2-positive Metastatic Breast Cancer
This is a prospective, open-label, multi-cohort, phase II study to evaluate the efficacy and safety of Oral metronomic capecitabine combined with pyrotinib in patients with HER2-positive advanced breast cancer who had received prior anti-HER2 ADC drugs (including T-DXd, SHR-A1811, T-DM1, etc.) before…
Longitudinal Tumor Burden Quantification Using Circulating Tumor DNA in Metastatic Lobular Breast Cancer
The goal of this study is to characterize early dynamic changes in ctDNA, which can aid in tailoring early therapy in patients with metastatic Invasive lobular carcinoma (ILC). Response assessment using ctDNA analysis could not only aid in de-escalation but also escalation…
MRI Screening for Brain Metastases Among Patients With Triple Negative or HER2+ Stage II or III Breast Cancer
The goal of this multi-centre, prospective study is to assess the frequency of asymptomatic brain metastasis in patients with stage IIb or III Triple Negative or HER2 positive breast cancer. The main questions it aims to answer are: 1. What proportion of…
Endogenous copper manipulation based on multifunctional gold nanoparticles elicit precise and self-reinforcing photothermal-chemodynamic therapy for effective treatment of metastatic breast cancer
Immunomodulatory and Ameliorative Effect of Citrus limon Extract on DMBA‐induced Breast Cancer in Mouse
Breast cancer is the most prevalent malignancy in the world and the leading cause of female cancer-related mortality. Several ways for combating this entity have been proposed, but a significant and effective cure has yet to be established. Natural compounds originating from…
Tumor Clusterin Expression at Diagnosis Is Associated with Residual Disease Burden After Neoadjuvant Chemotherapy in Breast Cancer
Objectives: Clusterin (CLU) has been implicated in cell survival and treatment resistance, but its relationship with pathological response to neoadjuvant chemotherapy in breast cancer remains unclear. We evaluated CLU expression in routine diagnostic specimens as a biomarker of pathological response and long-term…
A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer
The purpose of this study is to investigate the efficacy, safety, and tolerability of camizestrant in combination with ribociclib in patients with ER+ HER2- BC who have not received any other systemic treatment for advanced disease. Participants will be treated within the…
Genetic Testing in Predicting Tumor Response in Patients With Stage I-III HER2 Negative Invasive Breast Cancer
This phase II trial studies how well genetic testing works in predicting tumor response in patients with stage I-III HER2 negative invasive breast cancer. Genetic testing is a procedure that tests tumor samples to learn if certain genes are activated (turned on)…
NAUTILUS-04: No Axillary Surgical Treatment in Low-Risk Clinically Node-Negative Breast Cancer Without Whole-Breast Radiotherapy - A Prospective, Randomized, Phase III, Non-inferiority Clinical Trial
The safety of omitting sentinel lymph node biopsy (SLNB) has been established only in patients undergoing breast-conserving surgery with whole-breast radiotherapy, as demonstrated in the prior randomized trials. Whether SLNB can be omitted in patients who will not receive whole-breast radiotherapy remains…
Primary Breast Oligoprogressive Sites Treated With Radiotherapy to Obviate the Need to Change Systemic Therapy
This study assesses if metastasis-directed radiation therapy (Stereotactic body radiation therapy - SBRT) can delay a change in systemic therapy, and if circulating tumor cells in the bloodstream can help guide treatment options in metastatic breast cancer patients with progressive disease
AI-driven multi-omics biomarkers in precision breast cancer therapeutics: from discovery to clinical translation
Breast cancer is biologically heterogeneous, yet conventional clinical decisions rely on static, single-marker proxies (ER, PR, HER2, and Ki-67) that capture only a narrow slice of tumor biology. This mini-review argues that AI-driven multi-omics biomarkers offer a valuable shift toward systems-level, model-derived…
Patient Experiences After Risk-Reducing Mastectomy Among Women Carrying BRCA1/2 Pathogenic Variants Without a Diagnosis of Breast Cancer
This is a descriptive, exploratory cross-sectional, single-center national study. The study asks a sample of women carrying pathogenic variants associated with hereditary breast and ovarian cancer who have undergone risk-reducing mastectomy (MRR) and have signed informed consent to complete an interview developed…
Diary of Losing a Breast and Reflections on Mothering as an Arab
Drawing on scholarship in feminist studies, sociolinguistics, and cultural studies, this article-diary argues that motherhood—particularly as experienced by an Arab woman navigating personal loss, specifically the loss of a breast to cancer, and societal expectations—is not a static role but a dynamic…
Long non-coding RNA HANR modulates the glucose metabolism of triple negative breast cancer via stabilizing hexokinase 2
A nomogram model combining ultrasound-based radiomics features and clinicopathological factors to identify germline BRCA1/2 mutation in invasive breast cancer patients
Metastasis of Invasive Ductal Carcinoma of the Breast to the Uterine Cervix 30 Years Post‐Mastectomy: A Case Report
ABSTRACT Metastasis of invasive ductal carcinoma of the breast to the uterine cervix is rare, with only one report of a case occurring more than 20 years after the primary surgery. A 69‐year‐old woman presented with abnormal uterine cervical cytology (atypical glandular cells…
Antibody-based biosensor for breast cancer with ultrasonic regeneration
Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results
Disitamab vedotin triggers ferroptosis to activate CD8+ T-cell antitumor immunity in HER2-expressing breast cancer
Abstract Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is highly aggressive and is associated with poor prognosis after metastasis or recurrence. The development of anti-HER2 antibody–drug conjugates (ADCs) has markedly improved outcomes. Disitamab vedotin (RC48) is a novel anti-HER2 ADC…
CRISPR/Cas12a-confined cleavage molecular gating cascaded EXPAR for ultrasensitive detection of breast cancer ctDNA
Mannose-functionalized Liposomes for Synergistic Co-delivery of Doxorubicin and Suberoylanilide Hydroxamic Acid in Triple-negative Breast Cancer
Non-ionizing near-infrared radiation transillumination spectroscopy for breast tissue density and assessment of breast cancer risk
There is increasing attention to prevention as a means to reduce cancer incidence. Prevention interventions or therapies in turn rely on risk assessment programs to identify those women most likely to benefit from education and lifestyle changes. These programs are usually based…
Screening for the breast cancer gene (BRCA1) using a biochip system and molecular beacon probes immobilized on solid surfaces
We describe the use of a biochip based on complementary metal oxide semiconductor (CMOS) technology for detection of specific genetic sequences using molecular beacons (MB) immobilized on solid surfaces as probes. The applicability of this miniature detection system for screening for the…
Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies
Molecular targeting with exogenous near-infrared excitable fluorescent agents using time-dependent imaging techniques may enable diagnostic imaging of breast cancer and prognostic imaging of sentinel lymph nodes within the breast. However, prior to the administration of unproven contrast agents, phantom studies on clinically…
Portable near-infrared diffusive light imager for breast cancer detection
We present a frequency-domain near-infrared optical tomography system designed for breast cancer detection, in conjunction with conventional ultrasound. It features fast optical switching, three-wavelength excitations, and avalanche photodiode as detectors. Laser diodes at 660, 780, and 830 nm are used as light…
Spatial variations in optical and physiological properties of healthy breast tissue
Near-infrared (NIR) diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) show promise as noninvasive clinical techniques for breast cancer screening and diagnosis. Since NIR methods are based on optical contrast between healthy and diseased tissue, it is essential to characterize the…
Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study
No impact of parity on global gene expression levels in breast cancer tissue and normal breast tissue – a nested case-control study in the Norwegian Women and Cancer study
Abstract Background We have previously demonstrated that the linear decrease in postmenopausal breast cancer incidence with increasing parity is linked to expression changes in hundreds of genes in the peripheral blood cells of healthy women. However, these changes are not observed in…
Hereditary breast cancer: emerging roles of non-coding RNAs
Abstract Breast cancer remains a major global health burden and is characterized by substantial molecular and clinical heterogeneity. In recent years, considerable progress has been made in elucidating the genetic and molecular mechanisms underlying breast cancer, particularly those associated with hereditary susceptibility.…
In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy
Diffuse optical imaging (DOI) may be a beneficial diagnostic method for women with mammographically dense breast tissue. In order to evaluate the utility of DOI, we are developing broadband diffuse optical spectroscopy (DOS) to characterize the functional origins of optical signals in…
Mexican consensus on breast cancer 2025: multidisciplinary care for breast cancer
Second-harmonic generation in collagen as a potential cancer diagnostic parameter
The fibrillar collagen network in tumor and normal tissues is different due to remodeling of the extracellular matrix during the malignant process. Collagen type I fibers have the crystalline and noncentrosymmetric properties required for generating the second-harmonic signal. The content and structure…
Characterizing breast cancer tissues through the spectral correlation properties of polarized fluorescence
We study the spectral correlation properties of the polarized fluorescence spectra of normal and cancerous human breast tissues, corresponding to patients belonging to diverse age groups and socioeconomic backgrounds. The emission range in the visible wavelength regime of 500 to 700 nm…
Automated breast cancer classification using near-infrared optical tomographic images
An automated procedure for detecting breast cancer using near-infrared (NIR) tomographic images is presented. This classification procedure automatically extracts attributes from three imaging parameters obtained by an NIR imaging system. These parameters include tissue absorption and reduced scattering coefficients, as well as…
Digital optical tomography system for dynamic breast imaging
Diffuse optical tomography has shown promising results as a tool for breast cancer screening and monitoring response to chemotherapy. Dynamic imaging of the transient response of the breast to an external stimulus, such as pressure or a respiratory maneuver, can provide additional…
Fractal analysis for classification of breast carcinoma in optical coherence tomography
The accurate and rapid assessment of tumor margins during breast cancer resection using optical coherence tomography (OCT) has the potential to reduce patient risk. However, it is difficult to subjectively distinguish cancer from normal fibroglandular stromal tissues in OCT images, and an…
Remote positioning optical breast magnetic resonance coil for slice-selection during image-guided near-infrared spectroscopy of breast cancer
The design and testing of a pneumatic optical positioning interface produced with the goal of improving fiber positioning in magnetic resonance (MR)-guided diffuse spectral imaging of breast cancer is presented. The system was created for vertical positioning of optical fibers inside the…